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Medication can be an effective treatment option for patients with pulmonary embolism, especially when used in conjunction with behavioral techniques. Antidepressants have been shown to reduce the release of serotonin in the brain; these may include serotonin reuptake inhibitors (SSRIs) such as Paroxetine (Paxil, Pexeva, and Brisdelle) and Fluoxetine (Prozac). Tricyclic antidepressant clomipramine (Anafranil).